In 1981, the main known instance of AIDS — the last phase of a HIV contamination — was accounted for.
After six years, in 1987, the Food and Drug Administration (FDA) affirmed the principal tranquilize for the treatment of AIDS: zidovudine or azidothymidine (AZT).
Today, there are more than 30 FDA-affirmed drugs for the treatment of HIV/AIDS.
In any case, there is no medication as of now accessible that can free the assortment of HIV, curing the viral disease.
Rather, the solutions stifle the infection by meddling with its capacity to repeat in the body.
There are likewise two medications accessible that can keep you from contracting HIV:
Pre-presentation prophylaxis, or PrEP, which enormously diminishes your danger of getting to be distinctly tainted with HIV when taken each day
Post-presentation prophylaxis, or PEP, which lessens your danger of getting to be distinctly contaminated in the event that you take it inside three days of being presented to HIV
Classes of Antiretroviral Drugs
There are six classes of antiretroviral medications for HIV, each of which follow up on an alternate stride in HIV's replication cycle.
Individuals for the most part take three medications from two unique classes, which better control the infection and keep it from creating drug resistance.
This "mixed drink" treatment is called antiretroviral treatment (ART), or profoundly dynamic antiretroviral treatment (HAART).
The classes of medications include:
Nucleoside turn around transcriptase inhibitors (NRTIs, for example, zidovudine (Retrovir), abacavir (Ziagen), and emtricitabine (Emtriva), which piece invert transcriptase, a compound the infection needs to change over single-stranded HIV RNA into twofold stranded HIV DNA
Non-nucleoside invert transcriptase inhibitors(NNRTIs, for example, efavirenz (Sustiva), etravirine (Intelence), and nevirapine (Viramune), which tie to and change switch transcriptase
CCR5 rivals (likewise called section inhibitors, for example, maraviroc (Selzentry), which pieces CCR5, a receptor protein on the surface of CD4 cells (insusceptible framework cells) that the infection ties to enter the phone
Combination inhibitors, for example, enfuvirtide (Fuzeon), which likewise obstructs HIV's capacity to enter CD4 cells
Protease inhibitors, for example, atazanavir (Reyataz), ritonavir (Norvir), and tipranavir (Aptivus), which square protease, a protein HIV needs to duplicate and taint new cells
Integrase strand exchange inhibitors (INSTIs, for example, dolutegravir (Tivicay), elvitegravir (Vitekta), and raltegravir (Isentress), which square integrase, a compound the infection uses to coordinate its hereditary material into its host cell's DNA
There are likewise settled measurements mix antiretroviral prescriptions — single pills that contain numerous medications.
Moreover, pharmacokinetic enhancers, for example, cobicistat (Tybost), can expand the viability of the antiretroviral drugs (however they have no impact on the infection when utilized alone).
Pharmaceutical Side Effects
Symptoms and complexities of the different HIV pharmaceuticals can include:
#Paleness, a variation from the norm in red platelets
#Looseness of the bowels
#Cerebral pain and tipsiness
#Sickness and spewing
#Abnormal fat misfortune or fat development (lipodystrophy)
#Insulin resistance and expanded levels of blood glucose (hyperglycemia)
#Lactic acidosis, a development of lactic corrosive in the circulation system
#Swelling of the mouth or tongue
It's vital to talk about the greater part of the medicines and supplements you're bringing with your specialist in light of the fact that antiretroviral medications can associate with an extensive variety of different pharmaceuticals.
These incorporate yet are not restricted to:
Corrosive decreasing specialists and heartburn pharmaceuticals, including stomach settling agents, proton pump inhibitors, and H2 rivals
Medications and supplements that influence p-glycoprotein or the chemical CYP3A4, for example, St. John's wort
Substances that influence the action of the chemical cytochrome P450, for example, grapefruit juice.
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